Nidra Yoga and Ayurveda and other diseases

Introduction The increasing concentration of oxygen level in the atmosphere near about 2.5 billion ago, oxygenic photosynthesis by cyanobacteria leads to the evolution of aerobic respiration leading to the development of complex eukaryotic organisms. All the aerobic organisms  depends upon the cellular respiration and some of the derivatives of oxygen are highly toxic for the cells. Reactive oxygen species, reactive oxygen intermediates and reactive nitrogen species have been used to define the highly reactive oxygen bearing molecules. Hydroxyl and peroxyl radicals, hydrogen peroxide and superoxide radical anions are some of the species responsible for the damage of the fatty acids, DNA and proteins as well as other cellular components. The redox reaction is typically involved in controlling production of reactive oxygen and nitrogen species. They can, in turn, react with specific functional group of target proteins like clusters, cysteines  etc. that lead to covalent protein modificat

  Scientific Name Sanskrit Name Active compound Country year Sample Mechanism of Action Inference of the study Reference Withania Somnifera Ashwagandha Withaferine, 2. β sitosterol, withaferin A, stigmasterol, withanolide A, and withanolide D   India, 2.NR 1995, 2.2020 Rats, 2.NR 1.Choline acetyl transferase and Muscarinic cholinergic receptor binding were reversed 2. The active ingredients targets   pathways such as PI3K/Akt signaling, neurotrophin signaling and toll-like receptor signaling and proteins such as Tropomyosin receptor Kinase B (TrkB), Glycogen Synthase Kinase-3β (GSK-3β), Toll-Like Receptor 2/4 (TLR2/4), and β-secretase (BACE-1). 1.Effective 2. Effective 1.Bhattacharya et.al.1995 2. Hannah et. al. 2020 Curcuma Longa Haridra Curc